The center left the game in the first quarter after being floored by a collision with Bobcats point guard Kemba Walker.
Head coach Mike Woodson told reporters: "We don't know the severity yet. We'll know more [this] morning. He's a big piece of what we do. I got a lot to think about right now."
ESPN reports that Chandler may have suffered a sprain, but that further tests will be needed to assess the extent of the injury.