Giannis Antetokounmpo led the scoring for the Bucks with 30 points as they opened up a 2-0 lead in the best-of-seven series.
He added 17 rebounds and five assists, while Ersan Ilyasova came off the bench to score 17.
Milwaukee took an early lead at the Fiserv Forum, outscoring their opposition and enjoying a 64-39 lead at the halfway stage and pressed on to secure their sixth win by more than 20 points in this season's playoffs.
Kawhi Leonard top scored for the Raptors with 31 points.
The third game of the series will take place at the Scotiabank Arena on Sunday.