The 29-year-old will miss his third straight game when the Nets take on the Toronto Raptors on Tuesday night.
"It's frustrating. The first couple of days I was down just because it seems like I can't catch a break," he said, according to ESPN.
"It seems like I start feeling good and I just can't get into a rhythm because I can't stay on the floor."
Williams revealed that his ankle is day-to-day but it is even more sore after he sprained it again last week.