Kemba Walker led the way with 29 points as the Boston Celtics secured an eighth straight win with a 116-106 victory over the Dallas Mavericks.
Walker made a trio of key three-pointers in the fourth quarter to maintain Boston's momentum since a season-opening loss at Philadelphia.
Russell Westbrook had 26 points and Clint Capela added 11 and 20 rebounds to help the Rockets to a fourth straight win.
JJ Redick sunk 24 points for the Pelicans, who had fought back to trail 97-93 before Harden's scoring burst put the Rockets up 110-93 with just over five minutes left on the clock.
In Detroit, Andrew Wiggins scored 33 points as the Minnesota Timberwolves spoiled Blake Griffin's return from injury with a 120-114 win over the Pistons.
In Monday's other games, the Memphis Grizzlies beat the visiting San Antonio Spurs 113-109, the Los Angeles Clippers won 98-88 over the Toronto Raptors and the Utah Jazz beat the Golden State Warriors 122-108.