The winless Buccaneers held a 21-point lead at one stage in the second quarter, but Wilson threw for two touchdowns and ran for one of his own as Seattle pulled the scores back level before Steven Hauschka kicked the winning field goal in overtime.
The result gave the Seahawks a franchise record-equalling 12th consecutive home win, and Wilson was impressed with how his side responded to being so far behind.
"That was a huge win. You think about the deficit we were under and to be able to comeback in that fashion - that's big time," Wilson told The AP.
The Seahawks remain top of the NFC West with the victory having made their best ever start to an NFL season with an 8-1 record.