Wagner believes that his team are capable of playing man-to-man coverage during the game, while the Broncos frequently employ the use of crossing routes to leave defenders trailing and caught up in traffic.
The battle between the Seahawks defense and the Peyton Manning-led Broncos offense is likely to be a highlight of this year's season finale.
On Wednesday, Wagner told reporters: "They run a lot of crossing routes but they're not going to pick us off like that. We're too physical for that. We're not going to just sit there and let them pick us off. We're going to hit them.
"Target someone like and try to pick Kam Chancellor. They should see how that works out."
After being selected in the second round by the Seahawks during the 2012 Draft, Wagner played a key role as the team won the NFC this season.