The 49ers dominated their clash with the Jacksonville Jaguars cruising to a 42-10 victory and secure their fifth successive win.
Staley told reporters: "It was great. London has been a great host to us and we had a top-notch facility the whole week.
"I thought the players handled it well too. It was a unique experience, travelling as far as we did overseas, everybody was focused and locked in and we still understood we had business to do.
"We were happy with the result that we had today. Now we can get back to the States and back to the comforts of home."