The running back has recorded more rushing yards against the Seahawks than any other player.
The 30-year-old told the team's website: "If my o-line opens the holes, I'll run. Some of the times when I had success, that's what it was. My o-line did a great job.
"We'll see what they bring to the table. I want to see what they'll do now. [49ers quarterback Colin Kaepernick] showed he can run, throw, block, laughs, I want to see what they do now. It should be a good game Sunday."
The two sides meet at Century Link Field on Sunday.