The Jacksonville Jaguars have confirmed that they will play four regular NFL season matches at Wembley from 2013 to 2016.
The Jaguars will move one of their home games each season to Wembley as part of the NFL's mission to increase the sport's popularity outside of America.
NFL commissioner Roger Goodell said: "Our goal is to continually grow the game, and this commitment by the Jacksonville Jaguars represents a major step forward in our international efforts. We have had a tremendously positive reaction to our sport in the UK."
A total of 65,000 tickets have been sold for the game between the Rams and the Patriots, with more to be made available in September.