The 27-year-old has been out with a groin injury since the first game of the season, but has been practising for the past few weeks for Bill Belichick's side.
"Had a good day today," Amendola told reporters. "Had a good practice, ran around, made some plays and looking forward to Sunday, so we'll see.
"You miss it. You see your guys out there running around and making plays, and there's not really any positives from not being out with your team."
The Patriots are 4-0 going into week five of the season.