Rookie linebacker Kiko Alonso is second in the league in tackles so far this season with 81, as well as a sack, a forced fumble and four interceptions.
The Chiefs head coach told reporters: "Their front seven is one of the better ones we face, if not the best. They can bring it. The front guys bring it and those linebackers are extremely fast and athletic.
"Their rookie is right up there either leading the league in tackles or right up there in tackles. I know he's making a lot of tackles, you turn on the tape and see him running around making a lot of tackles. We have to make sure that we play very well against them."
The Bills are currently bottom in the AFC East, while the Chiefs have the last remaining unbeaten record in the NFL.