Reigning Super Bowl champions New England Patriots maintained their perfect start to the season with a hard-fought 16-10 victory over AFC East rivals Buffalo Bills.
The Patriots and Bills came into the clash at New Era Field with 3-0 records but the experience of quarterback Tom Brady, who notched his 31st NFL win against Buffalo, ultimately won it for the visitors despite a rare off night for the 20-season veteran.
Stephen Gostkowski kicked a decisive 23-yard field goal in the third quarter to make it four wins from four for the defending champions.
The Kansas City Chiefs scored a last-gasp touchdown to maintain their 100 per cent record with an enthralling 34-30 triumph at the Detroit Lions.
The Lions led 10-0 after the first quarter, only to trail 20-13 halfway through the third during an impressive spell for Kansas.
Matt Prater’s third-quarter field goal looked to have sealed a tight victory as Detroit added two touchdowns to the Chiefs’ one to edge ahead 30-27 deep into the final quarter.
The Los Angeles Rams suffered a surprise 55-40 defeat at home to the Tampa Bay Buccaneers.
The Rams – last season’s Super Bowl runners-up – fell to their first loss of the campaign as Tampa Bay’s Jameis Winston threw for four touchdowns.
Rams quarterback Jared Goff threw over 500 yards but was also intercepted three times.
The New Orleans Saints, still without star quarterback Drew Brees, saw off the Dallas Cowbosy 12-10 thanks to four field goals from Wil Lutz.
The Jacksonville Jaguars had kicker Josh Lambo to thank for securing a 26-24 win at the Denver Broncos, the Chicago Bears gained an important 16-6 success against NFC North rivals the Minnesota Vikings and the Seattle Seahawks eased to a 27-10 victory over the Arizona Cardinals.
Daniel Jones secured his second successive win as starting quarterback for the New York Giants after they defeated NFC East rivals the Washington Redskins 24-3.
Jones completed 23 of 31 passes for 225 yards as Wayne Gallman finished with two touchdowns in the one-sided win at the MetLife Stadium, with debutant Washington quarterback Dwayne Haskins throwing three interceptions.
Nick Chubb ran in three touchdowns as the Cleveland Browns secured a 40-25 success against fellow AFC North outfit Baltimore Ravens. The running back had 20 carries for 165 yards as the Browns improved their record to 2-2.
Austin Ekeler was in the end zone twice as the Los Angeles Chargers eased to a 30-10 win over the Miami Dolphins, while Joey Slye’s three field goals helped the Carolina Panthers on their way to a 16-10 victory at the Houston Texans.
The Tennessee Titans returned to winning ways with a 24-10 road victory at the Atlanta Falcons, with the Oakland Raiders beating the Indianapolis Colts 31-24.