It has been just two weeks since Pagano's men defeated the Titans, but the Colts coach has said that the previous game has no bearing on the upcoming clash.
Pagano told reporters: "Well, you certainly know each other when you play twice so quickly. I'm sure there will be a wrinkle here or there as far as the unknown that you might not have seen.
"From a preparation standpoint, having played only a couple weeks ago, you're going to continue to prepare the way you always prepare. Certainly they know us, and we know them. We're both fighting for the same thing."
The two sides are closely matched in the AFC South, with the division's playoff spot still up for grabs.