Seattle opened the scoring with 11:46 left in the first quarter when Steven Hauschka hit a 42-yard field goal to make it 3-0 to the visitors.
Seattle extended their lead by two more points when Pat McAfee's punt was blocked, resulting in a safety for the visitors as the ball went out of bounds.
The Colts hit back at the end of the first quarter, however, when Andrew Luck found TY Hilton with a long pass before the receiver cut inside and ran in from the 25-yard line to complete a 74-yard touchdown.
Indianapolis took the lead in the second quarter when they managed to block a field goal, allowing Delano Howell in for a 61-yard return score.
The Seahawks responded with 6:05 left of the half, however, as Jermaine Kearse produced a diving catch from Wilson's throw to complete a 28-yard score and make it 19-14 to the hosts.
Adam Vinatieri cut that lead to just three points before half time with a 41-yard field goal following a 58-yard drive from the visitors.